Consider a mitochondrion with a pH in the matrix = 8 and the pH of the intermemb

Question

Consider a mitochondrion with a pH in the matrix = 8 and the pH of the intermembrane space = 6.3. The matrix is 100 mV more negative than the IMS or cytoplasm. What is the proton motive force (p) across the mitochondrial membrane?

Answer: 200.3 mV

If the ratio of ATP to ADP and Pi is such that G for ATP hydrolysis = -60 kJ/mol, how many mols of H+ will have to move through the ATP synthase in order to generate a mol of ATP? [The answer should be whole number.]

Answer: _____mol

(I know the answer to the first part (200.3 mV), but I do not know how to do the second part.)

Explanation / Answer

If the ratio of ATP to ADP and Pi is such that G for ATP hydrolysis = -60 kJ/mol, how many mols of H+ will have to move through the ATP synthase in order to generate a mol of ATP?

5 mol

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