In mice, the following alleles were used in a cross: W = waltzing gait w = nonwa
ID: 58011 • Letter: I
Question
In mice, the following alleles were used in a cross:
W = waltzing gait w = nonwaltzing gait
G = normal gray color g = albino
B = bent tail b = straight tail
In a three-point testcross, a waltzing, gray, bent-tailed mouse heterozygous for all three genes is crossed to a nonwaltzing, albino, straight-tailed mouse, and the following progeny obtained:
waltzing gray bent 48
waltzing albino bent 63
nonwaltzing gray straight 57
nonwaltzing albino straight 66
waltzing gray straight 12
waltzing albino straight 15
nonwaltzing gray bent 15
nonwaltzing albino bent 18
A) Use Chi-square analyses to determine which of the three genes show evidence of linkage.
B) For any genes that show linkage, calculate their genetic distance.
Explanation / Answer
WGB
WGb
WgB
wGB
wgB
wGb
Wgb
wgb
wgb
WwGgBb
WwGgbb
WwggBb
wwGgBb
wwggBb
wwGgbb
Wwggbb
wwggbb
Phenotypes
Waltzing, gray , bent
Waltzing gray, straight
Waltzing, albino, bent
Non waltzing, gray, bent
Non-waltzing, albino, bent
Non-waltzing, gray, straight
Waltzing, albino, straight
Non-waltzing, albino, straight.
Observed values
48
12
63
15
18
57
15
66
Total= 294
Expected value is 294/8
36.75
36.75
36.75
36.75
36.75
36.75
36.75
36.75 51
Chi- square test=summation(observed- Expected)^2/ Expected = 113.45
3.44
16.68
18.75
12.87
9.56
11.15
12.87
23.28
WGB
WGb
WgB
wGB
wgB
wGb
Wgb
wgb
wgb
WwGgBb
WwGgbb
WwggBb
wwGgBb
wwggBb
wwGgbb
Wwggbb
wwggbb
Phenotypes
Waltzing, gray , bent
Waltzing gray, straight
Waltzing, albino, bent
Non waltzing, gray, bent
Non-waltzing, albino, bent
Non-waltzing, gray, straight
Waltzing, albino, straight
Non-waltzing, albino, straight.
Observed values
48
12
63
15
18
57
15
66
Total= 294
Expected value is 294/8
36.75
36.75
36.75
36.75
36.75
36.75
36.75
36.75 51
Chi- square test=summation(observed- Expected)^2/ Expected = 113.45
3.44
16.68
18.75
12.87
9.56
11.15
12.87
23.28
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