Human ABO blood type is determined by three alleles (IA , IB , and i) whose gene

Question

Human ABO blood type is determined by three alleles (IA , IB , and i) whose gene products modify the H antigen produced by protein activity of an independently assorting H gene. A rare abnormality known as the "Bombay phenotype" is the result of epistatic interaction between the gene for the ABO blood group and the H gene. Individuals with the Bombay phenotype appear to have blood type O based on the inability of both anti-A antibody and anti-B antibody to detect an antigen. The apparent blood type O in Bombay phenotype is due to the absence of H antigen as a result of homozygous recessive mutations of the H gene. Individuals with the Bombay phenotype have the hh genotype. Use the information above to make predictions about the outcome of the cross shown below:

I^A I^B Hh x I^A I^B Hh

Explanation / Answer

I^A I^B Hh x I^A I^B Hh

The cross produces the following outcome

AA HH, AB HH, AAHh, AA hh,

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