12.The rearrangement of T-form hemoglobin to the R-form: A) occurs in each prote

Question

12.The rearrangement of T-form hemoglobin to the R-form: A) occurs in each protein subunit independently when its heme binds oxygen. B) requires the binding of at least three oxygen molecules. C) increases the ion pairing interactions of the C-terminal amino acids. D) involves the movement of the Fe(II) into the heme plane. E) opens a central cavity for BPG binding. 13.If the binding of 02 to hemoglobin was characterized by a Hill constant of-1: A) hemoglobin would not be able to release bound 02. B) the O2 binding curve would be hyperbolic. C) the sequential model of allosterism would be eliminated as a reasonable model. D) the binding of the first O2 would decrease the affinity of the hemoglobin for O2 E) the binding of the first O2 would increase the affinity of the hemoglobin for O2 14·The Bohr effect is described as: a. prevention of the autoxidation of oxyheme by globin b. increase in pH stimulates Hb to bind oxygern c. binding of cO, to N-terminal amino groups of blood proteins to form carbamates d. the presence of BPG increases affinity of oxygen to hemoglobin 15. Binding of oxygen to Hb results in: a. positive heterotropic effect b. negative heterotropic effect c. positive homotropic effect d. negative homotropic effect 16. Which among the listed phenomena is not a characteristic of the symmetry allosteric MWC model a. symmetrical relationship between protomers in an oligomer b. each protomer can exist in at least two conformational states in an equilibrium c. ligand binds to a protomer in each configuration, but with different affinity d. conformational change takes place simultaneously for all protomers in an oligomer e. upon binding of a ligand there is a sequential change in the conformation of the protomers in the oligomer 17. The following equation for a tetramer: (s1 is known as: a. full allosteric equation b. Lineweaver-Burk equation c. Hill equation d. Michaelis-Menten equation e.simplified allosteric equation

Explanation / Answer

12) Answer: (D)

13) Answer: (B)

14) Answer: (B)

15) Answer : (A) Positive heterotopic effect

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