Which of the following is an example of RNA editing? The ApoB gene is methylated
ID: 58208 • Letter: W
Question
Which of the following is an example of RNA editing?
The ApoB gene is methylated in liver resulting in silencing of mRNA expression.
The ApoB gene is transcribed generating a C6666 to U6666 substitution which generates a stop codon and truncation of the encoded protein.
The ApoB gene is spliced generating a premature stop codon which results in a functionally truncated protein.
The ApoB gene is mutated during development from C6666 to T6666 which generates mRNA with a U6666 resulting in a stop codon
The ApoB gene is methylated in liver resulting in silencing of mRNA expression.
The ApoB gene is transcribed generating a C6666 to U6666 substitution which generates a stop codon and truncation of the encoded protein.
The ApoB gene is spliced generating a premature stop codon which results in a functionally truncated protein.
The ApoB gene is mutated during development from C6666 to T6666 which generates mRNA with a U6666 resulting in a stop codon
Explanation / Answer
The asnwer for RNA editing is
The ApoB gene is transcribed generating a C6666 to U6666 substitution which generates a stop codon and truncation of the encoded protein.
ApoB protein is expressed in cells of both the liver and the intestine.In both locations, transcription produces a pre-messenger RNA that must be spliced to produce the mRNA to be translated into protein.
In the Liver the process occurs normally producing apolipoprotein B-100 - a protein, containing 4,563 amino acids, that is essential for the transport of cholesterol and other lipids in the blood.
In the Intestine In the cells of the intestine, an additional step of pre-mRNA processing occurs: the chemical modification of the C nucleotide in Codon 2153 (CAA) into a U. This RNA editing changes the codon from one encoding the amino acid glutamine (Gln) to a STOP codon (UAA). Translation of the mRNA stops at codon #2153 forming apolipoprotein B-48 - a protein, containing 2152 amino acids that aids in the absorption of dietary lipids from the contents of the intestine.
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