1: MATCHING. Write the name of the filamentous protein that best matches each de

Question

1: MATCHING. Write the name of the filamentous protein that best matches each

description.

Filamentous Proteins:

Keratin

Collagen

Elastin

A. Contains proline and hydroxyproline

___________________________

B. Provides protection

________________________________

C. Has sheets_____________________

D. Provides support to skin and bones

________________________________

E. has two helices in a left handed coiled

coil ______________________

2: In almost all of the protein misfolding diseases that were presented in class, a misfolded

protein formed aggregates in tissues. These aggregates are then toxic to the tissues. Which

of the following statements best describes why these aggregates form?

A. The formation of the maximum number of hydrophilic interactions is energetically

favorable

B. There is a maximization of ionic interactions

C. There is a synergistic relationship between aggregates and the placement of polar amino

acid residues around the exterior of the protein.

D. There is a maximization of entropy of water molecule

E. The hydrogen bonding of water is minimized.

Explanation / Answer

A. Contains proline and hydroxyproline - Collagen ( present in skin)

B. Provides protection - Collagen and Keratin

C. Has beta sheets - Keratin

D. Provides support to skin and bones - Collagen ( present in tendons and skin)

E. has two helices in a left handed coiled coil - Keratin

2.

The formation of the maximum number of hydrophilic interactions is energetically favorable . It causes a rise in energy so the molecules are maximized and aggregates form.

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