Which of the following proteins promote cellular apoptosis? Bcl-2 Bax Bcl-xL bet
ID: 59449 • Letter: W
Question
Which of the following proteins promote cellular apoptosis?
Bcl-2
Bax
Bcl-xL
beta-actin
Question 2
Which change in PARP indicates activation?
methylation
phosphorylation
cleavage
nitration
Question 3
Which signaling pathway is activated by Ras in malignant leisions?
MAPK signaling
Nf-kB signaling
PIK3 signaling
Akt signaling
Question 4
Phosphorylation of and P65 result in what fate for Nf-kB?
degradation in the proteasome
nuclear export
translocation into the nucleus
cleavage and activation
Question 5
What is the importance of Kras in PDAC development?
It activates NF-kB signalling and Akt signaling
It inhibits caspase cleavage and apoptosis
It promotes phosphorylation of P65
It promotes PARP phosphorylation
Bcl-2
Bax
Bcl-xL
beta-actin
Explanation / Answer
Q 1). b. Bax
Apoptosis is the programmed cell death. Bcl-2 is anti-apoptotic, Bax- pro apoptotic, Bcl-xL - anti-apoptotic, beta-actin - one of the isoforms of actin.
Q 2). b. phosphorylation
Phosphorylation of PARP (poly ADP-ribose polymerase) activates it.
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