he problem below relates to the synthesis of several intermediates in the citric
ID: 59806 • Letter: H
Question
he problem below relates to the synthesis of several intermediates in the citric acid cycle, which is essential in the production of ATP through aerobic respiration. A set of experimental results relating the growth (+) of neurospora on several media (MM= minimal medium) is given in the table. Based on the information provided, present the biochemical pathway for the substances oxaloacetate, fumarate, malate, and succinate and locations of the metabolic blocks produced by the various strains. Strain, MM,MM (+ OXALOACETATE),Medium MM + fumarate,MM+ malate,MM+succinate l62, -, +, -, +, -, l36, -, +, -, -, -, l41, -, +, +, +, -,
Explanation / Answer
Strain 162 grows in the presence of oxalo acetate and malate this shows that the block is in the conversion of succinyl coA to succinate. fumarte to malate, hence grows in the presence of malate.
Strain 136 - Block in the conversion of succinyl CoA to succinate; Succinate to fumarate and to malate
Strain 141 - Block only at succinate to fumarate conversion, hence grows in the presence of fumarate.
Strain MM MM+OO MM+F MM+M MM+S 162 - + - + - 136 - + - - - 141 - + + + -Related Questions
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