Answer the followng questions about a strand of DNA that has the following seque
ID: 59869 • Letter: A
Question
Answer the followng questions about a strand of DNA that has the following sequence: TAC ACC AAT CAA AAA ATT
a, Write the sequence of the nucleotide strand made during DNA replication.
b. if the original DNA is transcribed , what will the nucleotide sequence of the resulting mRNA read?
c. write the amino acid sequence of the final peptide when this mRNA is translated
d. what is the impact on the amino acid sequence if the DNA is mutated so that the sequence of nucleotides is : TAC ACT AAT CAA AAA ATT?
e. if this mutation ocurred in a tumor supressor gene, how would it affect the rate of the cell cycle and why
f. if this mutation ocurred in an oncogene , how would it affect the rate of the cell cycle and why?
Please I need help, can you also post a link or explanation that will help me to figure it out and understand the concept. Thank you
Explanation / Answer
Based on the given data,
The Given strand is:
TACACCAATCAAAAAATT
a
The sequence of the nucleotide strand made during DNA replication:
5’-TACACCAATCAAAAAATT-3’
3’-ATGTGGTTAGTTTTTTAAA-5’
b)
mRNA:
5’-UACACCAAUCAAAAAAUU-3’
c)
Amino acid sequence:
N terminal-Tyr-Thr-Asn-Gln-Lys-Ile-C terminal
d)
The mutated sequence is as follows:
5’-TACACTAATCAAAAAATT-3’
It gives mRNA:
5’- UACACUAAUCAAAAAAUU-3’
Therefore, the amino acid sequence is:
N terminal-Tyr-Thr-Asn-Gln-Lys-Ile-C terminal
e)
A tumor suppressor gene is normal cellular gene that regulates the cell proliferation or DNA repairing proteins which may cause genome instability. A mutation such as recessive loss of function mutation in a tumor suppressor gene may inactivate it and results in the uncontrolled cell proliferation causing the cancer.
However, it would it affect the rate of the cell cycle, because the normal and mutated DNA code for same protein sequence.
f)
Oncogene is a tumor causing gene, and the proteins coded by these genes always inhibit the process of apoptosis and promote uncontrolled cell growth. However, it would it affect the rate of the cell growth, because the normal and mutated DNA code for same protein sequence.
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