4. In running column chromatography under the following conditions, you get resu

Question

4. In running column chromatography under the following conditions, you get results that are less than ideal. Consider the situation in each case and suggest a correction. a. You run a column on a mixture of two unknown halogenated alkenes, but hey both elute from the column at the same time. The solvent used was methylene choride (dichloromethane). b. You run an alumina column on a mixture of a thiol and an amine, but you never get any compound off the column (i.e. neither compound elutes form the column). The solvent was a mixture of petroleum ether and dichloromethane.

Explanation / Answer

1) in first case the polarity of the solvent is very high, hence both the compounds are eluted once. If the polarity of the solvent is decreased(i.e. a mixture of Dichloromethane and petroleum ether) then both elute separately. 2) In the second case, polarity of the solvent is very low, Hence they do not elute at all. Increasing the polarity of the solvent.

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