Histone deacetylase (HDAC) has been shown to be capable of either increasing or

Question

Histone deacetylase (HDAC) has been shown to be capable of either increasing or decreasing gene expression, depending on the protein on which it acts (histones versus other proteins involved in gene expression). Given this information, how might HDAC inhibitors act to treat some forms of cancer? Select all plausible explanations. Given this information, how might HDAC inhibitors act to treat some forms of cancer?

Select all plausible explanations.

HDAC inhibitors may decrease expression of anti-division genes.

HDAC inhibitors may increase expression of anti-division genes.

HDAC inhibitors may decrease expression of pro-division genes.

HDAC inhibitors may increase expression of pro-division genes.

Explanation / Answer

Histone deacetylases are a class of enzymes that removes acetyl groups from the N-acetyl lysine amino acids of the histone proteins. Thus, returning the negative charge to the histones, this results in the wrapping of DNA around histone more tightly. Tightly wrapped DNA is less likely to be expressed.

The correct explanation for the given case might be HDAC (Histone deacetylase) inhibitors may increase expression of anti-division genes and HDAC inhibitors may decrease expression of pro-division genes that are normally involved in the progression of cell division and results in cancer.

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