Targeting transgenes into a mouse occurs when: A targeting plasmid which contain

Question

Targeting transgenes into a mouse occurs when:

A targeting plasmid which contains no sequence homology replaces the original by reverse

transcription

A targeting plasmid which contains a similar sequence to the target gene replaces

the original by homologous recombination

targeting plasmid which contains a similar sequence to RNA Pol II is inserted randomly

into the genome by reverse transcription

All of the Above

A targeting plasmid which contains no sequence homology replaces the original by reverse

transcription

A targeting plasmid which contains a similar sequence to the target gene replaces

the original by homologous recombination

targeting plasmid which contains a similar sequence to RNA Pol II is inserted randomly

into the genome by reverse transcription

All of the Above

Explanation / Answer

Targeting transgenes into a mouse occurs when a targeting plasmid which contains a similar sequence to the target gene replaces the original by homologous recombination. This process used in production of knockout mice.Knockout mouse can be defined as a genetically modified organism, in which the gene of interest is inactivated or knocked out of the organism’s body.

Thus, the correct option is (b).

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