Suppose that a mutation occurs in the middle of a large intron of a gene-encodin

Question

Suppose that a mutation occurs in the middle of a large intron of a gene-encoding a protein. What will the MOST likely effect of the mutation be on the amino acid sequence of that protein? The protein would likely be altered significantly as all mutations have deleterious effects. The amino acid sequence would be the same, as this type of mutation results in substitution with a chemically similar amino acid. The mutation may or may not affect the intron removal depending on whether nucleotides affecting splicing are altered. The amino acid sequence would be the same, as introns are removed during post-transcriptional processing. The amino acid sequence would be the same, as this is a silent mutation in which the altered codon encodes the same type of amino acid. Suppose that a mutation occurs in the middle of a large intron of a gene-encoding a protein. What will the MOST likely effect of the mutation be on the amino acid sequence of that protein? The protein would likely be altered significantly as all mutations have deleterious effects. The amino acid sequence would be the same, as this type of mutation results in substitution with a chemically similar amino acid. The mutation may or may not affect the intron removal depending on whether nucleotides affecting splicing are altered. The amino acid sequence would be the same, as introns are removed during post-transcriptional processing. The amino acid sequence would be the same, as this is a silent mutation in which the altered codon encodes the same type of amino acid.

Explanation / Answer

Answer

Mutation in intron does not result in any change in sequence of amino acids as they as they are splice out before translation of mrna. But if mutation result in incorrect splicing of intron it can then this can have a dramatic effect on the gene expression because the sequences in the intron will be translated into protein .So correct answer is 3-The mutation may or may not affect the intron removal depending on whether nucleotides affecting splicing are altered.

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