Hi Please help with this genetics question! Part B (a) The even-skipped (eve) ge

Question

Hi Please help with this genetics question!

Part B

(a) The even-skipped (eve) gene and and enhancer modules Adjacent genes ADAM EVEN-SKIPPED (EVE APPLE mRNA DNA 7.4 -5.5-3.9 +1.5 +3.2+4.8 +6.6 +8.4 kb eve enhancer modules stripe number Giant Krüppel eve repressors Stripe 2 enhancer module eve activators: Bicoid Hunchback (b) Distribution of gap gene expression Anterior Posterior Position of 2nd stripe relative to gap gene hunchback ant expression Krüppel bicoid Gap expression Parasegment 1 (c) Occupancy of regulatory sites on eve stripe 2 enhancer module in different parasegments In parasegment 3 (eve stripe 2) Bicoid Hunchback In parasegment 3, the concentration of the activators bicoid and hunchback is high, while the concentration of repressors Krüppel and Giant is low,causing activation of eve in stripe 2 In parasegments 2 and 4, eve is not activated because repressor sites are occupied by Giant and Krüppel Giant In parasegment 2 (no eve activation) Bicoid Krüppel In parasegment 4- (no eve activation) Hunchback © Pearson Education, Inc.

Explanation / Answer

Part-A: option 1 is correct

Part-B: in the order only giant and bicoid, only hunchback and bicoid, Krupple, hunchback and bicoid Bicoid, Hunchback, activate, parasegment 3

Part-C: option 1 is correct

Part-D: option 3 is correct

Part-E and F: option 2 is correct (because in 2 and 4 already they have occupied by repressors like giant and krupple). If you mutate either bicoid or hunchback that may diminish the transcription of parasegment 3 but not stop the transcription. If you mutate both at a time that affects parasegment3 transcription.

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