Tips: In autosomal dominant conditions, every afflicted individual has, at least

Question

Tips:

In autosomal dominant conditions, every afflicted individual has, at least, one parent with the affliction.

In autosomal recessive conditions, it is possible for afflicted individuals to sometimes have two parents that are both “normal” in phenotype, which would mean both parents are only carriers.

In X-linked recessive conditions, all, or most, afflicted individuals are male. Females of afflicted sons are carriers, and have “normal” phenotypes.

Problem: Pedigree 2

Which set of genetic disorders below follow the inheritance basis traced in this pedigree?

Achondroplasia, Familial hypercholesterolemia, Huntington's disease, Marfan syndrome

Albinism, Cystic fibrosis, Phenylketonuria (PKU), Tay-Sachs disease

Duchenne muscular dystrophy, Fragile X syndrome, Hemophilia A, Red-green colorblindness

Explanation / Answer

the given pedigree exhibits autosomal dominant disorder. The genetic disorders Familial hypercholesterolemia, Huntington's disease, Marfan syndrome are inherited in the autosomal dominant fashion.

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