a. Start with a population that has a gene with two alleles (A and a) with class

Question

a. Start with a population that has a gene with two alleles (A and a) with classical Mendelian dominance that are at equal frequency (p = 0.5. q = 0.5). Calculate the expected genotype frequencies: AA = Aa = aa = b. Now assume some environmental change that makes the recessive phenotype completely unfit (fitness = 0). Calculate the allele frequencies and genotype frequencies in the second generation. (Hint: Your calculations might be easier if you assume a population size of 100) p = AA = q = Aa = aa = What was the reduction in the frequency of the recessive allele from generation #1 to generation #2? c. Assuming the same fitness for the recessive phenotype, calculate the allele frequencies and genotype frequencies in the third generation. p = AA = q = Aa = aa = What was the reduction in the frequency of the recessive allele from generation #2 to generation #3? d. There a difference in the change in allele frequencies between generations even though the level of selection remained the same. Why? e. What type of selection is this and what would happen if we continued this process over many generations?

Explanation / Answer

1. p=0.5 q= 0.5. genotype frequency of AA is p2= (0.5) (0.5) = 0.25 ; Aa= 2pq= 2x 0.5x 0.5= 0.5 ; aa= 0.5x0.5 = 0.25

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