This is a Peanut Allergy Study. summarize the methods section and summarize the

Question

This is a Peanut Allergy Study.

summarize the methods section and summarize the results section:

Methods:

Infants between the age of 4 and 11 months who had severe eczema, egg allergy, or both were selected. There were two study cohorts (those who showed no sensitivity to peanuts, while the other group showed a wheal measuring 1 to 4 mm in diameter). Any infant that had a wheal greater than 4 mm was not selected for the study based on the risk of having a serious reaction. Each of the two cohorts was randomly assigned to an experimental group. The control group was given a diet that avoided peanut foods and the exposure group was fed 6 grams of peanut-containing foods spaced out into at least 3 different exposures per week until they reached the age of 60 months. Compliance was measured through a food frequency questionnaire and through testing of bedding at the age of 60 months for peanut particulate matter to verify their exposure. The actual numbers of male versus female participants was never clearly stated. However, 64.8% of the avoidance group were males compared to 55.2% of the consumption group

Results:

Infants who did not have any response to the initial skin test were given 5 grams of peanut in a single dose. The immune IgE response was measured to determine if an allergy was present. For participants who had shown a small reaction to peanut initially were given a double blind placebo controlled trial where a total of 9.4 grams of peanut were administered in increments to determine if a current allergy was present (this was done to keep the participants safe from a severe reaction).

Among the 542 infants in the group with a negative result on the initial skin-prick test, 530 (97.8%) could be evaluated for the primary. At 60 months of age, 13.7% of the avoidance group and 1.9% of the consumption group were allergic to peanuts; this absolute difference in risk of 11.8 percentage points (95% confidence interval [CI], 3.4 to 20.3; P<0.001) represents an 86.1% relative reduction in the prevalence of peanut allergy.

All 98 children in the group with positive results on the initial skin-prick test were evaluated. At 60 months of age, 35.3% of the avoidance group and 10.6% of the consumption group were allergic to peanuts; the absolute difference in risk of 24.7 percentage points (95% CI, 4.9 to 43.3; P=0.004) represents a 70.0% relative reduction in the prevalence of peanut allergy.

Explanation / Answer

Methods:

Infants of age 4 to 11 months with severe eczema or egg allergy or both were selected. They were categorized into two groups, of which one group does not have sensitivity towards peanuts and other group of sensitive to peanuts and having a wheal of 4mm. These two groups were set up as experimental groups. The control was also set up and was not given peanut s in the diet. Experimental group were fed with 6 grams of peanuts in the diet 3 times per week till the infants reached 60 months of age. Frequent questionnaire and observation of bedding for particulate matter at the age of 60 months was carried out. The number of male and female participants is not clearly known but the group avoided with peanut diet was contained 64.8% males and group fed with peanut diet contained 55.2% females.

Results:

Infants without any response to the initial skin test were given 5 grams of peanut in a single dose. The immune IgE response was measured to determine allergy response. For participants who had shown a small reaction to peanut initially were given a double blind placebo controlled trial where a total of 9.4 grams of peanut were administered in increments to determine immediate allergic response.

Among the 542 infants in the group with a negative result on the initial skin-prick test, 530 (97.8%) could be evaluated for the primary allergic response. At 60 months of age, 13.7% of the avoidance group and 1.9% of the consumption group were allergic to peanuts. This finally suggests that 86.1% relative reduction in the prevalence of peanut allergy.

All 98 children in the group with positive results on the initial skin-prick test were evaluated. At 60 months of age, 35.3% of the avoidance group and 10.6% of the consumption group were allergic to peanuts; these results suggest that 70.0% relative reduction in the prevalence of peanut allergy.

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