4. One goal of tissue engineering is to develop surrogate tissues that can be im
ID: 62410 • Letter: 4
Question
4. One goal of tissue engineering is to develop surrogate tissues that can be implanted in a wound bed to enhance healing. Such tissue surrogates usually contain a suspension material such as fibrin or collagen, molded in a matrix and embedded with fibroblasts, which are cells that help speed up incorporation of the tissue. These wound beds are hypoxic, meaning that oxygen levels are very low compared to those they would normally experience. Discuss how metabolic processes in the fibroblasts could be engineered to increase their survival and growth when implanted. Include details of relevant pathways, etc.Explanation / Answer
Tissue engineering is a potential tool to regenerate the damaged tissues Growth factors are a key component of tissue engineering and act as signaling molecules to stem cells, regulating their biological responses and tissue differentiation. Growth factors are a promising tool to target specific tissue reactions, their involvement in important regulatory mechanisms and in cellular functions, including adhesion, proliferation, migration, and differentiation in the epithelium, bone, and soft connective tissues and nerves etc
Fibroblast growth factor (FGF) is mainly found to be involved in the repair and regeneration of tissues. FGF was identified as a protein capable of promoting fibroblast proliferation and is composed of 22 protein members. FGFs exhibit various functions by binding and activating the fibroblast growth factor receptors (FGFRs). The main signaling pathway is the stimulation of FGFRs by the RAS/MAP kinase pathway. These efficient functions made the FGFs to be utilized for the regeneration of damaged tissues, including skin, blood vessel, muscle, adipose, tendon/ligament, cartilage, bone, tooth, and nerve.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.