Which of the following CORRECTLY outlines the role of alternative splicing in th
ID: 62580 • Letter: W
Question
Which of the following CORRECTLY outlines the role of alternative splicing in the control of sex differentiation in Drosophila? Female flies alternatively splice mRNA from the male pronucleus to determine if the zygote will develop as a male or female. Alternative splicing allows male flies to produce sperm with either an X or a Y chromosome, causing sex differentiation. Alternative splicing early in embryonic development allows males and females to produce distinct products from the same genes, leading to sexually dimorphic flies. Alternative splicing can only occur in fully differentiated cells and therefore cannot contribute to sex differentiation. Alternative splicing generates X:A ratio of 0.5 in females and X:A ratio of 1.0 in males, where Tra protein mediated splicing only takes place in males. Which of the following CORRECTLY outlines the role of alternative splicing in the control of sex differentiation in Drosophila? Female flies alternatively splice mRNA from the male pronucleus to determine if the zygote will develop as a male or female. Alternative splicing allows male flies to produce sperm with either an X or a Y chromosome, causing sex differentiation. Alternative splicing early in embryonic development allows males and females to produce distinct products from the same genes, leading to sexually dimorphic flies. Alternative splicing can only occur in fully differentiated cells and therefore cannot contribute to sex differentiation. Alternative splicing generates X:A ratio of 0.5 in females and X:A ratio of 1.0 in males, where Tra protein mediated splicing only takes place in males.Explanation / Answer
The process that correctly outlines the role of alternative splicing in the control of sex differentiation in Drosophila is as follows:
In Drosophila a set of embryonic genes expresses during embryonic development and alternatively splice themselves and produce a protein called Doublesex (Dsx) transcription factor. This transcription factor expresses another protein called Sex-lethal (Sxl) protein. If a gamete has produced functional Sxl proteins after alternative splicing, it will become developed into a female. . If a gamete has produced non-functional Sxl proteins after alternative splicing, it will become developed into a male and has only Dsx proteins.
Therefore, the correct option is (c).
Alternative splicing early in embryonic development allows males and females to produce distinct products from the same genes, leading to sexually dimorphic flies.
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