Based on what you know about acetylcholine receptor signaling, what do you predi

Question

Based on what you know about acetylcholine receptor signaling, what do you predict would be the most likely outcome of treating a normal vascular endothelial cell with acetylcholine on the activities of PKC and GS in this same cell?

A. PKC would be activated 50%; GS would be inhibited 50%

B. PKC would be activated 50%; GS would be inhibited 100%

C. Both PKC and GS would be activated 100%

D. PKC would be activated 100%; GS would be inhibited 100%

E. PKC would be completely inactive: GS would be 100% active

Explanation / Answer

The most likely outcome of treating a normal vascular endothelial cell with acetylcholine on the activities of PKC and GS in this same cell is PKC would be activated 100%; GS would be inhibited 100%. This is because the acetyl choline triggers G- protein activity along with phospholipase C. Phospholipase C acts on phosphatidyl ionositolpolyphosphate into IP3 and DAG. IP3 activates Ca2+ ions release from ER lumen. The Ca released activates the phosphokinase C and this inturn activates several other enzymes. Thus, option D is correct.

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