a) In the brain, neuron 1 releases the neurotransmitter GABA and neuron 2 releas

Question

a) In the brain, neuron 1 releases the neurotransmitter GABA and neuron 2 releases glutamate. Neuron 2 contains GABAA receptors and neuron 3 contains AMPA receptors and releases acetylcholine. If neuron 1 is depolarized enough for an action potential, what will happen to neuron 3? Explain.

Note: assume that neuron 2 is affected directly by neuron 1 only and neuron 3 is affected directly by neuron 2 only

b) What would happen if neuron 1 was an acetylcholine neuron and neuron 2 had nicotinic receptors?

Explanation / Answer

Ans- GABA is an inhibitory neurotransmitter which on release reduces the neuronal excitability of central nervous system. So when the neuron1 is depolarized nerve impulse will be generated and its synaptic terminals will release GABA . GABA will bind to its receptor located on neuron 2 and it will cause decrease in the glutamate release. Due to low glutamate less acetylcholine will be released from neuron 3 and it will reduce the excitability of brain. Ans-b) as acetylcholine is a stimulatory neurotransmitter , it will stimulate neuron 2 and it will release glutamate which will also excite neuron 3

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