Part A Researchers (Wilson & Tan, 2002) made the following observations regardin

Question

Part A Researchers (Wilson & Tan, 2002) made the following observations regarding the heat-shock regulatory system in Chlamydia trachomatis:

(1) A regulator protein (call it R) binds to a cis-acting DNA element (call it D).

(2) R and D function as a repressor-operator pair.

(3) R functions as a negative regulator of transcription.

(4) D is composed of an inverted-repeat sequence.

(5) Repression by R is dependent on D being supercoiled.

Based on this information, which of the following might explain the heat-dependent regulation of metabolism in Chlamydia trachomatis ? Select all mechanisms that are supported by the information provided.

Heat changes the shape of R, which allows R to bind to D.

Transcription is inhibited by heat shock.

Heat causes D to supercoil, which allows R to bind to D.

Transcription is inhibited by heat shock. Heat causes D to uncoil, which prevents R from binding.

Transcription is stimulated by heat shock.

Heat changes the shape of R and prevents R from binding to D.

Transcription is stimulated by heat shock.

Explanation / Answer

Heat causes D to uncoil, which prevents R from binding.

Heat changes the shape of R and prevents R from binding to D.

Transcription is stimulated by heat shock.

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