96 EXPERIMENT 15B Procedure table of the reactant/solvent physical properties is
ID: 637312 • Letter: 9
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96 EXPERIMENT 15B Procedure table of the reactant/solvent physical properties is detailed below: Ammonium acetate 9596 ethanol Methyl Ethy (36% wt aqueous solution Reagent acetoacetate acetoacetate Formula Ct 02 Equiv MW 52 30.03 g/mol 7708 g/mol 46.07 g/mol 116.12 g/m 130.14 g/mol 1.076 g/mL Density 1.029 g/mL 1.09 g/mL 0.789 g/mL Volume 810 HL 960 ?L 280 ?? Mass .61 430 mg 5.58 110-112 mmol 7.51 -80 169-170 7.59 -43 181 3.66 -114 78 . Place the following in a 10-mL round-bottom flask equipped with a magnetic stir bar: methyl acetoacetate (810 HL) OR ethyl acetoacetate (960 uL); ammonium acetate (430 mg) and 36% wt, aqueous formaldehyde (280 L). Add all liquid reagents with an au- Clamp the flask in a room-temperature water bath, attach an air condenser, and heat After 10 minutes at 80 °C, stirring will stop due to accumulation of solid product. Once Add 5 mL of distilled water to the flask and use a glass rod to break up the solid prod- tomatic delivery pipette. 2. the mixture gradually to 80 °C with vigorous stirring. 3. this occurs, remove the flask from the water bath. 4. uct and grind it into a fine powder. Isolate the crude product via vacuum filtration and wash thoroughly with distilled water (10 mL). Recrystallize the crude solid product from 95% ethanol (use a 50-mL Erlenmeyer flask). Let the flask cool to room temperature and then place in an ice bath for 10 minutes to ensure complete precipitation Isolate the purified solid via vacuum filtration. Weigh and calculate the percentage yield for the reaction. Take appropriate physical measurements (mp, IR) to ascertain the purity of your compound, comparing with literature data where possible.Explanation / Answer
4. Pharmacophore is a part of a molecular structure that is most important for a reaction. It acts as the center due to which a compound undergoes a biological or a pharmacological reaction. An example is benzodiazepine binding site on the GABA receptor. Only a few centres are involved in the binding.
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