What would be the result of a mutation in Hsp90? Glucocorticoid receptor could n

Question

What would be the result of a mutation in Hsp90?

Glucocorticoid receptor could not form a dimmer

The nuclear localization signal would no longer function

Expression of the regulated genes would become constitutive

The hormone would not be able to bind to the glucocorticoid receptor

Glucocorticoid receptor could not form a dimmer

The nuclear localization signal would no longer function

Expression of the regulated genes would become constitutive

The hormone would not be able to bind to the glucocorticoid receptor

Explanation / Answer

c. Expression of the regulated genes would become constitutive.

Hsp90 (heat shock proteins 90) is actively invovled in the regulation of cell cycle. Mutation in heat shock protein allows the constitutive expression of regulated genes, which leads to the generation of cancer cells.

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