(Problem 7) How do transcriptional activator proteins and repressors affect the

Question

(Problem 7) How do transcriptional activator proteins and repressors affect the level of transcription of eukaryotic genes? Activators proteins and repressors bind to each other to form a dimer that can attach to RNA polymerase and serve as an ''on'' or ''off'' switch. Activator proteins form pores in the nucleus to allow the import of RNA polymerase from the cytoplasm, and repressors block these pores. Activator proteins and repressors bind to cis elements on the DNA and promote or prevent, respectively, the assembly of the basal transcription factor apparatus. Activator proteins create a pool of ATP molecules needed for transcription and repressor proteins block ATP production, thereby inhibiting transcription. Activator proteins generally introduce more methylations to the DNA, while repressors do the opposite action to the DNA.

Explanation / Answer

activator proteins form pores in the nucleus to aloow the import of rna polymerase from the cytoplasm, and the repressor block these pores.

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