A hypothetical three-step metabolic pathway consists of the intermediates W, X,
ID: 64072 • Letter: A
Question
A hypothetical three-step metabolic pathway consists of the intermediates W, X, Y, and Z, and the enzymes that catalyze the reactions A, B, and C. Determine the order of the metabolic pathway and the enzymes that catalyze the reactions based on the following information:
1) An inhibitor of enzyme B causes Z to build up
2) An organism with a mutation in enzyme C requires Y to grow.
3) An inhibitor of enzyme A causes W, Y, and Z to build up.
4) An inhibitor of enzyme C causes W and Z to build up.
Provide your answers using capital letters and place the enzymes that catalyze each reaction in between the intermediates (e.g. WAXBYCZ would be the answer if the pathway was W -> X -> Y -> Z and the enzymes A, B, and C catalyze the first, second, and third reactions respectively).
Explanation / Answer
This belongs the uracil synthesis the main enzymes are carbomylphosphatase synthase , aspartate transcarbamoylase and thymidine phosphorilase.
Thymidin phosphorilase is the novel inhibitor. So what ever loss of function mutants cannot be re-activated. The pathway is for the synthesis of uracil. if any genes are inactivated the cell will not be able to grow. But ,if you provide uracil in the media the cell will be able to grow regardless of whether any of the enzyme A,B or C are functional since the cell no longer needs to use those enzymes in the synthesis of uracil
The pathway W-----------X_------------- Y-----------Z
catalyzed by the enzymes A,B and C in order the enzyme A is to produce X, So that X can be used to create Y and Z. If you supply the cell with X,Y or Z enzyme A is no longer required for the survival of the cell because the cell no longer needs to produce X,Y or Z on its own
Y is the product of C if C is inhibited there is no Y product and Z
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