3. Sickle-Cell Anemia is caused by an inherited autosomal hemoglobin which leads

Q: 3. Sickle-Cell Anemia is caused by an inherited autosomal hemoglobin which leads

3. a. Autosomal recessive gene is a gene that needs two alleles to express the trait. A single allele of this is not enough to manifest the traits. b. 50% of children have the chance of getting sickle-cell anaemia. c. 25% of children will be carriers. d. The second child has 50% probability of having the disease.

ID: 64182 • Letter: 3

Question

3. Sickle-Cell Anemia is caused by an inherited autosomal hemoglobin which leads to sickle shaped red blood cells. Two carriers mate. a. Explain what is meant by an autosomal recessive gene. b. What is the probability that their first child will have sickle cell anemia? c. What Is the probability that a child will be a carrier? d. Their first child is born and does have sickle-cell anemia. What is the probability that their second child will be born with the disease? 4. Cystic Fibrosis is caused by an autosomal recessive gene that causes the production of excessively thick mucus in humans. The abnormal mucus interferes with both lung and intestinal function, potentially leading to death. A healthy woman mates with a man who has cystic fibrosis. a. Are the genotypes of the parent's definitive? Why or why not? b. What are the genotypes of the parents? c. What is the probability that this couple has a child with cystic fibrosis? d. If they have a second child, does the probability change? 5. Both Phenylketonuria (PKU) and Tyrosinemia are caused by autosomal recessive genes that prevent the metabolism of the amino acids phenylananine and tyrosine, respectively. If ones diet is not adjusted early in life to reduce the Intake of these amino acids, PKU can cause mental retardation and Tyrosinemia can cause liver damage due the buildup of these amino acids. Two carriers for both diseases mate. What is the probability that their child will: a. Have both diseases? b. Have just one of the diseases? c. Be a carrier for both diseases? d. Be healthy (disease free) and not be a carrier?

Explanation / Answer

a. Autosomal recessive gene is a gene that needs two alleles to express the trait. A single allele of this is not enough to manifest the traits.

b. 50% of children have the chance of getting sickle-cell anaemia.

c. 25% of children will be carriers.

d. The second child has 50% probability of having the disease.

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3. Shown is a pedigree depicting a family in which some members are affected by

3. Sickle-cell anemia is a striking example of the drastic effect a single amino

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3. Sickle-Cell Anemia is caused by an inherited autosomal hemoglobin which leads

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