Predict the phenotype of a cell with a mutation that prevents phosphorylation of

ID: 64327 • Letter: P

Question

Predict the phenotype of a cell with a mutation that prevents phosphorylation of an ERM protein:

cells will have a disordered cell cortex, staining for actin will show little to no staining around the edges of the cell

cells will not express transmembrane proteins, resulting in reduced signaling

All are possible outcomes

cells will be unable to enter mitosis, staining for ?-TuRC will show failure to organize mitotic spindle

cells will have a disordered cell cortex, staining for actin will show little to no staining around the edges of the cell

cells will not express transmembrane proteins, resulting in reduced signaling

All are possible outcomes

cells will be unable to enter mitosis, staining for ?-TuRC will show failure to organize mitotic spindle

Correct option is A). Phosphorylated form of ERM binds Actin filaments to the edges of the cell to organise cortex.

ERM has a role in mitosis but in anchoring of mitotic spindle, its assembly will be unaffected.

Transmembrane proteins will be expressed on the cell surface but will not be able to interact with ERM for activation.

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