A) On the chart below, draw growth curves for the plus end and minus end of acti

Question

A) On the chart below, draw growth curves for the plus end and minus end of actin filaments, if one end has a critical concentration of 2 M and the other end has a critical concentration of 4 M. Label which end is the plus end and which is the minus end. Be sure the slope of each growth curve is consistent with the relative dynamics of each end.

20

15

10

5

0

-5 1 2 3 4 5 6 7

Y axis: Growth rate

x axis: Actin monomers (M ) *This is supposed to be a graph, not a table. X axis: actin monomers and Y axis: growth rate

B) If you added actin filaments of a defined length at the following concentrations: 1.5 M, 3.5 M and 6.5 M, would you expect the filaments to grow or shrink at their plus and minus ends?

Conc. 1.5M :

Conc. 3.5M :

Conc. 6.5 M :

C) TRUE or FALSE. Treadmilling requires that the addition rate at one end of a filament percisely match the subtraction rate at the oter end of the filament. Briefly explain your answer.

Explanation / Answer

B. The actin assembly and disassembly always remain the equlibrium

Conc 1.5uM: The filaments shrink at the minus end.

Conc 3.5uM: The filaments remains the same length

Conc 6.5uM: The filaments grow at the plus end.

C. The statement is True.

The cytoskeleton is a highly dynamic part of a cell and cytoskeletal filaments constantly grow and shrink through addition and removal of subunits.

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