Determine whether the phrase describes glucokinase, hexokinase isozymes I-III, o

Question

Determine whether the phrase describes glucokinase, hexokinase isozymes I-III, or all hexokinase isozymes. Note: Assume that the kinetic behavior of hexokinase isozymes in vivo is similar to in vitro (plot shown above). Note: If any part of this question is answered incorrectly, a single red X will appear indicating that one or more phrases have been placed incorrectly. Categories:

[- (Glucokinase), (Hexokinase 1,2,3), (All hexokinase isozmes (1-4)) ]

Select which of 3 options each # fits into

1. when blood glucose levels fall below normal range, maintains max velocity

2. subcellular localization is regulated by fructose 6-prosphate

3. not sensitive to inhibition by glucose 6-phosphate

4. plays an important role in liver regulation of blood glucose level

5. when blood glucose is low, will cause cells to trap glucose by phosphorylation

6. will be saturated by noraml blood glucose concentrations

7. present in tissues that sense blood glucose levels

8. will phosphorylate several hexoses including glucose

Explanation / Answer

1. when blood glucose levels fall below normal range, maintains max velocity-

Glucokinase

2. subcellular localization is regulated by fructose 6-prosphate - Glucokinase

3. not sensitive to inhibition by glucose 6-phosphate - Hexokinase IV

4. plays an important role in liver regulation of blood glucose level - Hexokinase IV or glucokinase

5. when blood glucose is low, will cause cells to trap glucose by phosphorylation -Hexokinase 1, 2 and 3

6. will be saturated by normal blood glucose concentrations -Hexokinase 1,2and 3

7. present in tissues that sense blood glucose levels - glucokinase or hexokinase IV

8. will phosphorylate several hexoses including glucose - all hexokinase isozymes

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