In order to better understand the specificity of different receptor tyrosine kin

Question

In order to better understand the specificity of different receptor tyrosine kinases, you generate a series of chimeric receptors. You know that the human epidermal growth factor receptor (HER1) binds epidermal growth factor (EGF), while fibroblast growth factor receptor (FGFR) binds to fibroblast growth factor (FGF). You made a chimeric transmembrane receptor that is the fusion between the extracellular domain of HER1 and the intracellular domain of FGFR. What is the most likely response to the addition of EGF? No signaling response. An FGF cellular response, as is typical in fibroblast cells (i.e., induction of a gene expression program typically induced downstream of FGFR activity). An EGF cellular response, as is typical in epidermal cells (i.e., induction of a gene expression program typically induced downstream of HER1 activity). Tyrosine phosphorylation along the chimera FGFR domain. Both B and D.

Explanation / Answer

C. An EGF cellular response, as is typical in epidermal cells (i.e., induction of a gene expression program typically induced downstream of HER1 activity)

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