aninglearning come Oft J Map CEDIA Determine whether the phrase describes glucok

Question

aninglearning come Oft J Map CEDIA Determine whether the phrase describes glucokinase, hexokinase isozymes I-Ill, or all hexokinase isozym Note: Assume that the kinetic behavior of hexokinase isozymes in vivo is similar to in vitro (plot shown above). Note: If any part of this question is answered incorrectly, a single red X will appear indicating that one or more phrases have been placed incorrectly. X Glucokinase (Hexokinase IV) HexOkinase I, II, or III All hexokinase isozymes (-IV) subcellular localization is regulated by fructose 6-phosphate when blood glucose levels fall below normal range, maintains maximum velocity will phosphorylate several hexoses including glucose not sensitive to inhibition by glucose 6-phosphate plays an important role in liver regulation of blood glucose level when blood glucose is low, will cause cells to trap glucose by phosphorylation Km is in the range of physiologic blood glucose levels will be saturated by normal blood glucose concentrations Incorrect . At least one phrase is misplaced. Use the plot to estimate the Km for the isozymes. Tissues that serve as a sensor of blood glucose levels must have a hexokinase isozyme that is responsive to blood glucose levels of 4-6 mm. O Previous ® Give Up & View Solution S Try Again O Next Exit EH

Explanation / Answer

Glucokinase -

1. Subcellular localization is regulated by fructose-6-phosphate.

2. Plays an important role in liver regulation of blood glucose level,

3. Not sensitive to inhibition by glucose-6-phosphate,

4. Km is in the range of physiologic blood glucose level,

5. Will be saturated by normal blood glucose concentrations.

Hexokinase I,II & III

1. When blood glucose levels fall below normal range, maintains maximum velocity,

2. When blood glucose is low, will cause cells to trap glucose by phosphorylation

All hexokinase isozymes I - IV

1. Will phosphorylate several hexoses including glucose

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