1. By ignoring a checkpoint in the cell cycle, a cancer cell may A. divide after

Question

1. By ignoring a checkpoint in the cell cycle, a cancer cell may

A. divide after mutations are fixed

B. Divide before its DNA is completely repicated

C. Condensed its chromosomes before mitosis

D. Align chromosomes on the equator of the cell during metaphase

E. Pull chromosomes apart during anaphase

2. All of the following are correct about HER2 except:

A. It is a protein associated with receptor for epidermal growth factor(EGF)

B. Most colon cancers have excess copies of this protein on their cells

C. A mutation can lead to an overproduction of HER2 on cells

D. Cells that overproduced HER2 are killed preferentially by the immune system when monoclonal antibodies are given therapeutically

E. Cells that produce too much HER2 can become cancerous

Can you explain why? Thanks

Explanation / Answer

1. B. Divide before its DNA is completely replicated

Checkpoints in cell cycle generally ensure the DNA replication and cell cycle only during favourable conditions. Cancer cells overcome the check points and undergo mitosis.

2. B. Most colon cancers have excess copies of this protein on their cells ---> FALSE (HER 2) is associated with breast cancer.

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