For problems 5-10, use the following information. Many members of the Fugate fam
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Question
For problems 5-10, use the following information. Many members of the Fugate family in Kentucky are blue -- the color of their skin not the content of their mood. Blue skin is caused by a mutation in the CYB5R3 gene, with CYB5R3D representing the dominant allele and CYB5R3r representing the recessive allele. The Fugate family is of European origin, and parents of blue children usually have white skin color. (see: Trost, C. 1982. The Blue People of Troublesome Creek. Science 82: 35-39.)
9. If the white skinned parents of a blue child have a second child, what are the chances that this second child will be blue?
10. A family in which the mother and father are both white skinned have a son with blue skin. If the mother and father also have a daughter, what are the chances her genotype is CYB5R3D / CYB5R3D?
1/8Explanation / Answer
Based on the given data, the blue is a mutant of gene CYB5R3 (92 His Tyr on the -chain of hemoglobin) and this gene encodes NADH-methemoglobin reductase. The expression of blue color in a population is Quasidominant or pseudodominant pattern. In Quasidominant or pseudodominant pattern the character is expressed only in homozygous condition, while in heterozygous state they are asymptomatic and act as carriers.
In this condition, blue color is expressed in the offspring, when two heterozygous carriers who are asymptomatic. Therefore, white skin is a recessive condition (CYB5R3r), while blue is a dominant condition (CYB5R3D).
9.
Based on the above information the chance of having a second blue child is ¼. This is because there are four different combinations of children (RR, Rr, Rr, and rr) are possible for each time.
Hence, the correct option is ¼.
10.
Based on the above information the chance of having a second blue child is ¼. This is because there are four different combinations of children (RR, Rr, Rr, and rr) are possible for each time.
Hence, the correct option is ¼.
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