A brain tumor has a lower concentration of water than surrounding healthy tissue

Question

A brain tumor has a lower concentration of water than surrounding healthy tissue. The T1 value of the protons in the tumour is shorter than that of the protons in healthy tissue, but the T2 value of the tumour protons is longer. Which kind of weighting should be introduced into the imaging sequence in order to ensure that there is contrast between the tumor and healthy tissue. If a large concentration of superparamagnetic contrast agent is injected and accumulates in the tumor only, which kind of weighting would now be optimal?

Explanation / Answer

Diffusion-weighted magnetic resonance imaging (DW-MRI) ,Perfusion-weighted MRI, Diffusion-tensor MRI and Dynamic Contrast-Enhanced (DCE) T1-weighted imaging depends on the microscopic mobility of water can be used to have a contrast between tumor and healthy tissues. This will help to identify the biological abnormality.

DW-EPI (Diffusion-weighted single and double spin-echo Stejskal-Tanner echo planar image (EPI) experiment) is useful to analyze the large concentration of superparamagnetic contrast agent.

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