Below you will find a diagram of the VEGF signaling pathway. Using the diagram a

Question

Below you will find a diagram of the VEGF signaling pathway. Using the diagram and the description, create a linear molecular pathway. Include arrows to indicate activating relationships between two molecules or inhibitory signs to indicate inhibitory relationships. (10pts) Figure 1: Binding of Vascular Endothelial Growth Factor (VEGF) to the VEGF receptors causes the receptor to dimerize. Dimerization results in the phosphorylation of the VEGFR intracellular domain. Proteins which recognize the phosphorylated form of VEGFR will pbosphorylate and activate Akt. Phosphorylated Akt will inhibit Caspase-3. Activated Caspase-3 breaks down the DNAse inhibitor. The DNAse inhibitor binds DNAse, which prevents DNAse from cleaving DNA into small fragments. Does VEGF activate or inhibit Daase? (2pts) Why? (4pts)

Explanation / Answer

1. VEGF (Vascular endothelial growth factor) inhibits Dnase. The following are the series of events that occur upon the activation of VEGF receptors.

VEGF binds to the VEGF receptors ----------> Dimerization and phosphorylation of VEGFR intracellular domain ---------> Phosphorylation of Akt (activated) ------------> Inhibition of capsase 3 ----------> Breakdowns DNAse inhibitor ----------> DNAse inhibitor binds with DNAse ----------> Inactivation of DNAse.

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