Receptor tyrosine kinases are activated by hormones that cause cell division (mi

Question

Receptor tyrosine kinases are activated by hormones that cause cell division (mitogens). Which of the following describes a way that a protein in the pathway could be mutated to result in its constitutive activation causing unregulated cell division?

A. a mutation in MAPK that removes one of its phosphorylation domains B. a mutation in the receptor that removes an important tyrosine from the cytoplasmic tail C. a mutation in Grb2 that changes its SH2 binding domain D. a mutation in Ras that makes it unable to hydrolyze GTP

Explanation / Answer

Ras protein that binds with GTP plays a role in signal regulation. Ras has the ability to hydrolyze GTP into GDP and becomes inactivated. So, a mutation is Ras that makes it unable to hydrolyze GTP results in continuous action and causes unregulated cell division.

Hence, the correct option is (D) a mutation in Ras that makes it unable to hydrolyze GTP.

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