26. With regards to allergic contact dermatitis which of the rolnowiis a) The ex

Question

26. With regards to allergic contact dermatitis which of the rolnowiis a) The extent of the response is always dose dependent. b) The extent of the response is generally not dose dependent. c) Allergic contact dermatitis is more common than irritant contact dermatitis. d) Allergic contact dermatitis is usually not associated with erythema (redness) 27. Which of the following is not true regarding the skin: a) it is an important route of exposure b) the thickness is not the same over the entire body c) to produce a systemic effect a chemical must reach the dermis d) it is a good barrier to lipophilic compounds 28. Which of the following biological factors affecting percutaneous absorption a) Condition of the skin b) Anatomical site c) Skin age d) All of the above 29. The source of all keratinocytes is the a) stratum basale b) stratum germinativum c) stratum corneum d) stratum spinosum e) stratum granulosum 30. The toxic effects of chemicals are determined by all of the following except: a. b. c. d. The nature of the chemical hazard The dose or quantity of the chemical The exposure pathway The manufacturing process 31. Advantages of in vivo studies include a. b. c. d. inexpensive toxicant effects can be studied under well-controlled conditions structural variations between species are minimal results depend on self-reporting 32. Any test for toxicity must include the following to be meaningful: a. an appropriate biological model b. well developed protocol c. end point that can be qualitatively and quantitatively assessed d. all of the above e. none of the above 33. Which is not an example of a toxicological endpoint? a. necrosis b. inflammation c. ionic bonding d. lipid peroxidation

Explanation / Answer

Ans 26 : a) The extent of the response is always dose dependent

The elicitation response of this dermatitis is strictly dose dependent , and this is the reason it differs from the other immune reactions. It is less common than the other type : i.e. irritant contact dermatitis (ICD). It is the major form of autotoxicity in humans.

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