Human ABO blood groups are controlled by a single gene with three alleles IA, IB

Question

Human ABO blood groups are controlled by a single gene with three alleles IA, IB, and i. The three alleles contribute to four blood group phenotypes. In addition to the ABO blood groups, there are two other loci that control blood phenotypes, the MN blood group locus and the Rh factor locus. The MN blood group has two codominant alleles, LM and LN. The Rh factor locus also has two alleles, Rh and Rh-, where Rh is dominant. The two phenotypes at the Rh+ factor locus are Rh+ and Rh-. Suppose in a population, the frequency of the ABO allele IA is 0.36, and the IB allele frequency is 0.26. In the same population, the frequency of the LM allele is 0.47, and the frequency of the Rh is 0.62.

What is the frequency of the genotype IBi LMLN Rh+ Rh+ if the population is in Hardy–Weinberg equilibrium?

Explanation / Answer

Frequency of IB= 0.26

Frequency of LM= 0.47

Frequency of LN= 1- LM= 1-0.47= 0.53

Frequency of Rh+= 0.62

Hardy weinberg equation= p2+2pq+q2

=(0.26)2 + 2 x 0.47 x 0.53 + (0.62)2

= 0.0676 + 0.282 + 0.3844

=0.734

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