Biochemistry Informatics - Biosignaling and the KEGG Database Below are directio

Question

Biochemistry Informatics - Biosignaling and the KEGG Database

Below are directions

http://www.kegg.jp

http://pid.nci.nih.gov/PID/2007/071009/full/pid.2007.2.shtml

1. What does the box labeled "INSR" refer to, and how many amino acids are found in this protein? A. Insulin; 1382 B. Insulin receptor; 1382 C. Insulin; 4149 D. Insulin receptor; 4149 2. For INSR, the membrane-bound location of this protein is while the dephosphorylated form of this protein, the active (or sensitized) state, is indicated by the symbol A. indicated by the 2 thick parallel gray lines on the map; +p B. indicated by the 2 thick parallel gray lines on the map; -p C. directly stated in the KEGG page for INSR; +p D. directly stated in the KEGG page for INSR; -p 3. Which protein serves as a branching point for the activation of glycolysis, antilipolysis (or inhibition of free acid release from the adipose tissue), antiapoptosis, and glycogenesis? A. RAC serine/threonine-protein kinase B. 3-phosphoinositide dependent protein kinase-1 C. insulin receptor substrate 1 D. phosphatidylinositol 3,4,5-trisphosphate

Explanation / Answer

1. The answer is option B. The box INSR refers to insulin receptor and it has 1382 amino acids.

2. The answer is option B. The membrane-bound location is indicated by the 2 thick parallel gray lines on the map; and the dephosphorylated state is mentioned as -p.

3. The answer is option A i.e. RAC serine/threonine-protein kinase.

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