We can prepare the mRNA for mitotic cell cycle kinase (Cdk1) and mitotic cyclin

Question

We can prepare the mRNA for mitotic cell cycle kinase (Cdk1) and mitotic cyclin protein (M cyclin), translate them in vitro, purify them and combine them. But when we inject them into a cell such as a G2 oocyte, this complex will not push the cell over the checkpoint into M. Which of the possible explanations for this, below, is most accurate?

A) The M cyclin/Cdk1 complex is degraded too quickly to act within the oocyte.
B) The M cyclin/Cdk1 complex is not responsible for the transition from G2 to M, you need a different set of Cdk and cyclin proteins.
C) The M cyclin/Cdk1 complex must be translated in the cell in which it will function in order to be active.
D) The M cyclin/Cdk1 complex must be both phosphorylated and dephosphorylated in order to be active.
E) The M cyclin/Cdk1 complex must be phosphorylated in order to be active.

Explanation / Answer

the possible explanations for this, below, is most accurate:

The correct answer is option D) The M cyclin/Cdk1 complex must be both phosphorylated and dephosphorylated in order to be active.

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