10. In the question above, why would inviability result from some segregation pa
ID: 71111 • Letter: 1
Question
10. In the question above, why would inviability result from some segregation patterns? • an extra chromosome would lead to lethality • translocation breakpoints within necessary genes would produce inviable gametes • it is important which centromere a part of a chromosome is attached to • deficiencies would occur for chromosomal regions involved in the translocation
11. When crossovers occur within pericentric inversions, which of the following is the cause of inviability in gametes or zygotes? • two breaks in one chromosome decrease viability • pairing is prevented within the inversion • recombinant chromosomes lack centromeres • large deletions lead to genetic imbalance
12. Which of the following could be characteristic of a pericentric inversion, but not of a paracentric inversion? • presence of an inversion loop • different orientation of some bands • altered location of the centromere • lack of recombination within the breakpoints
13. Which chromosome mutation involves no change in the overall amount of genetic material, is generally viable as a homozygote and shows no particular abnormalities at the phenotypic level? • deletion • duplication • inversion • translocation
14. If the expression of a normally recessive allele is observed in a heterozygote, this would be an example of • modified genic expression • pseudodominance • translocation • dominance mutation
15. Crossovers occur but recombinants are not recovered in _____, while crossovers never occur in _____. • deletions - translocations • deletions - inversions • translocations - inversions • inversions - deletions
16. A method for amplification of specific genes without cloning is • gene saturation blot • restriction digest • polymer hybridization • polymerase chain reaction
17. Where are the sequences used for identifying RFLPs for DNA profiling or mapping disease genes most likely to be found? • regulatory sequences • introns of structural genes • exons of structural genes • within the centromeric sequences
18. The DNA sequences used to conduct an RFLP type DNA profile are obtained from • the coding regions of genes • short sequences that may be repeated a variable number of times • sequences that vary little within a population • genes used to synthesize tRNA and rRNA
Explanation / Answer
10. translocation breakpoints within necessary genes would produce inviable gametes
11. large deletions lead to genetic imbalance
12. altered location of the centromere
13. inversion
14. pseudodominance
15. inversions - deletions
16. polymerase chain reaction
17. regulatory sequences
18. genes used to synthesize tRNA and rRNA
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