On your computer’s browser, view the page accessed by the URL: http://genome.ucs

Question

On your computer’s browser, view the page accessed by the URL: http://genome.ucsc.edu/cgi-bin/hgGateway . In the “Search Term” box at the top of the page, type “CFTR” (for the CFTR generesponsible for cystic fibrosis), and click on the result in the drop-down menu that appears, and click“Submit”. You will be directed to a window showing the organization of the CFTR gene on humanchromosome 7. At the top of this window are control buttons that allow you to move your view to the leftor right, zoom in (even to the level of the nucleotide sequence), zoom out, , or (on the second row) jump toa different chromosomal position. Below these buttons is a diagram, called an ideogram, of thechromosome you are viewing, with a region in red indicating the particular region of the chromosome youare looking at. You can also click on the ideogram to move around. Answer the following questions – noexplanation is necessary.

a. How many exons are in the CFTR gene?

b. In which exon(s) is (are) the 5’ UTR? The 3’ UTR?

c. In which direction is the CFTR gene transcribed: toward the centromere, or away from the centromere?

d. Is the CFTR gene located on the short arm (the p arm) or the long arm (the q arm) of human

chromosome 7?
Now zoom out the view by 10X.

e. What are the names of the genes that flank CFTR on either side? Are these genes transcribed from thesame strand of chromosome 7 as CFTR, or from the other strand?

Explanation / Answer

a)

chr7:117,479,963-117,668,665 Size: 188,703

Total Exon Count: 27 Strand:

b)

c) away from the centromere

d) the CFTR gene located on the long arm (the q arm) of human

chromosome 7

e) Orthologous Genes

UCSC ID: uc064hkg.1

This gene transcribed from the same strand of chromosome 7 as CFTR

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