A man’s leg was crushed between a car bumper and a wall. His physicians believe

Question

A man’s leg was crushed between a car bumper and a wall. His physicians believe their patient has suffered kidney damage from myoglobin blocking glomerular pores. Tests showed the following results:

                                Plasma creatinine                                            30 mg/dL plasma

                                24 hr urine specimen                                      volume = 1 liter

                                Urine creatinine                                               30 mg/ml urine

                A. How many mg of creatinine are in the urine specimen? How much creatinine appears in the urine per hour?

                B. What is the patient’s creatinine clearance in mL/min?

                C. What is the patient’s GFR?

                D. Is this a normal GFR? Did the patient sustain kidney damage?

Explanation / Answer

A. Volume of urine in one hour is 1000ml/24=42ml

Each ml contain 30 mg creatinine so per hour creatinine 42x30=1260 mg/hour

B. For calculating creatinine clearance we need to know patient age, weight.

however it would vary around 2.3 to 2.5 ml/min

C. GFR would be 2 mL/min/1.73 m2

D. 90mls/min/1.73m2 is normal value for GFR so it is not normal and so there is chance pt got some kidney problem too.

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