Name Lab Partner Number PHYSIOLOGICAL CHEMISTRY LAB SUPPLEMENTAL PRE LAB QUESTIO
ID: 717282 • Letter: N
Question
Name Lab Partner Number PHYSIOLOGICAL CHEMISTRY LAB SUPPLEMENTAL PRE LAB QUESTIONS ACTIVE INGREDIENT IN ASPIRIN 4. What information does the FDA require on the label for medicines? 5. Give two (2) reasons fillers are used in medicine tablets. 6. What laboratory apparatus is used to grind the aspirin tablets? 7. How many grains of acetylsalicylic acid are in a baby aspirin (81 mg)? Show all calculations. 8. Why in this experiment do you measure the amount of filler to determine the amount of acetylsalicylic acid in an aspirin tablet?Explanation / Answer
4. FDA requires following information on the lable of a medicine:
5. Fillers serve to keep the API stable, help its absorption, and simplify the manufacturing process.They help ensure that products are consistent form batch to batch.
6. Mortar and pestle is used to grind medicine tablets in the lab. A ball mill is another option.
7. 1 grain = 0.065 g = 65 mg
Based on this info, baby aspirine should contain (81/65) = 1.25 grains of acetylsalicylic acid.
8. A simple mass balance can be used to answer this question.
Mass of tablet = Mass of acetylsalicylic acid + Mass of filler
If we're able to determine the mass of filler, we can easily determine the mass of drug present in a tablet.
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