Which of the following pairs of cancer hallmarks would be most directly eliminat

Question

Which of the following pairs of cancer hallmarks would be most directly eliminated if you could restore p53 function (e.g., with a chaperone therapy) in tumor cells? A. “Replicative immortality” & “Inducing angiogenesis”. B. “Replicative immortality” & “Activating invasion & metastasis”. C. “Sustaining proliferative signaling” & “Resisting cell death”. D. “Sustaining proliferative signaling” & “Activating invasion & metastasis”. E. “Resisting cell death” & “Evading growth suppressors.”
Which of the following pairs of cancer hallmarks would be most directly eliminated if you could restore p53 function (e.g., with a chaperone therapy) in tumor cells? A. “Replicative immortality” & “Inducing angiogenesis”. B. “Replicative immortality” & “Activating invasion & metastasis”. C. “Sustaining proliferative signaling” & “Resisting cell death”. D. “Sustaining proliferative signaling” & “Activating invasion & metastasis”. E. “Resisting cell death” & “Evading growth suppressors.”

Explanation / Answer

The correct option is ....................... E. “Resisting cell death” & “Evading growth suppressors.”

Normal cells have a definite replicative ability. An intrinsic cellular mechanism allows the normal cells to divide to a definite number of times and blocks division beyond that limit. Cancer cells overcome this through telomerase over expression and allow the cells to continue proliferating through enabling replicative immortality and activating invasion and metastasis. This process is also aided due to loss of tumour suppression genes such as p53 which is a tumour suppressor.

The cancerous cells proliferate with the following features..............

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