You have developed a mouse strain called XYZ that models the autiimmune disease

Question

You have developed a mouse strain called XYZ that models the autiimmune disease pemphigus, where autoantibodies are made that destroy the tight junctions in the dermis, resulting in blisters and exfoliation. This leads towards the life-threatening disease. As mice develop the disease over their first 24 weeks of age, the severity can be scored on a scale of zero (least severe) to five (most severe). Assume that you bred these mice to TRL7 qne TLR9 knockouts, creating both since and double knockouts.

Below is the question I need help with:

1a. What conclusions can you draw about the roles of TLR7 and TLR9 in your model? Explain your reasoning.

1b. What do you conclude from the double KOs?  Explain your reasoning.

Explanation / Answer

From the given data,

1a)

The gene TLR7 has less expressivity, therefore it can synthesize low amount of auto antibodies, and therefore it has least severity until it reach 24 weeks of age. The gene TLR9 has more expressivity, therefore it can synthesize high amount of auto antibodies starting from 6 weeks, and therefore it has more severity.

1b)

In double KO TLR7/9 the gene TLR7 inhibit the expression of TLR9 gene, by acting as cis-acting element. Therefore, the double KO has less severity.

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