You review a grant application for $30,000 to sequence 3 human genomes. A child

Question

You review a grant application for $30,000 to sequence 3 human genomes. A child with a well-known dominant, fully penetrant, simple Mendelian inherited (not a complex trait) mutation causing a genetic disease and the child's two parents that do not have the disease are to be sequenced. The genetic disease is well known but has not previously been mapped in the genome. The proposal seeks to identify the specific gene and mutation responsable by comparing the childs genome to the two parents. What do you write in your review?

Explanation / Answer

The correct answer will be c. as the cause of mutation can be any.

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