How would you determine if the exocytosis (7) and endocytosis (7) of the beta 2

Question

How would you determine if the exocytosis (7) and endocytosis (7) of the beta 2 receptor is still occurring. What are the drawbacks of your approach (6). (10 sentences maximum for each) 4) How would you test if your peptide is folded correctly in the cells without having to determine its structure. (Hint, what signaling pathways get activated by unfolded proteins (3 approaches) (10). How would you block these pathwaysthat are activated specifically for your peptide (3 approaches) (10). What are the disadvantages and advantages of your method (3 each) (5). Maximum 10 sentences each.

Explanation / Answer

In response to the body ingesting something containing glucose, the beta cells in the pancreas will release insulin via exocytosis.If we detect presence of insulin we can conclude that exocytosis is occuring.

Endocytosis results in ending the signal (also known as signal attenuation) by removing the ligand and destroying the receptor. If the signal is not stopped, the cell will produce insilin in large amount. This could lead to excessive insulin in blood and hence can be detected.

If a protein needs to fit into a receptor molecule, the misfolded form may not fit properly and therefore not activate the receptor.

Related Questions

Navigate

• Browse (All)
• Browse H
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.