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Below is an example of a Glucose Tolerance Test (GTT) In the normal subject (blu

ID: 74475 • Letter: B

Question

Below is an example of a Glucose Tolerance Test (GTT)

In the normal subject (blue curve), the blood glucose levels peak then starts slowly going down. What is/are possible explanations for this decrease?

a. Blood insulin levels increase leading to an increase in localization of glucose transporters to the surface of cells in the muscle and adipose.

b. Blood insulin levels increase leading to an increase in localization of glucose transporters to the surface of cells in the liver and brain.

c. There is an uptake of glucose into the organs

d. A and C

e. B and C

250 O 200 9 Diabetic subject g 150 C 100 Normal subject 50 2 Time after oral glucose (hr) Fasting plasma glucose concentration 6

Explanation / Answer

d. A and C

Insulin is a pancreatic enzyme that catalyses the conversion of glucose into glycogen. Thus, it plays a very important role in blood glucose levels maintenance.

In a healthy person, after intake of food, blood insulin levels increase leading to an increase in localization of glucose transporters to the surface of cells in the muscle and adipose (uptake by organs by means of insulin).

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